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KMID : 0369820060360010011
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Jorunal of Korean Pharmaceutical Sciences
2006 Volume.36 No. 1 p.11 ~ p.17
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Preparation and Release Characterization of Osmotic Granule Nifedipine Delivery System
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정성찬/Jeong SC
조영호/이수영/이봉/김문석/강길선/이해방/Cho YH/Lee SY/Lee B/Kim MS/Khang GS/Lee HB
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Abstract
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The objective of this study was to confirm the effect of the type of dissolution media and paddle speed on nifedipine (ND) release profile from osmotic granule and the storage stability. Osmotic granule was manufactured by fluidized bed coating method. At each coating step, morphology of osmotic granule was differed. The size of osmotic granule was $750\;{\mu}m$ 수식 이미지 at 3 wt% membrane thickness. ND release was changed in diverse dissolution media, paddle speed. ND release is governed by not only osmotic pressure but diffusion from osmotic granule. ND release from osmotic granule decreased as storage period increased. These may be caused by liquid excipient which has low molecular weight. Storage stability of osmotic granule could be improved by removing liquid excipient from semipermeable membrane.
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KEYWORD
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Nifedipine, Osmotic granule, Fluidized bed coating, Drug release profile, Storage stability
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